Prue Talbot, a Professor of Molecular, Cell and Systems Biology and an ETOX faculty member, and Man Wong, a Genetics graduate student, have investigated the toxicity of methylglyoxal and acetaldehyde in human bronchial epithelial tissues. Both of these compounds are formed during the vaping of liquids containing propylene glycol. Their results, recently published in the journal Frontiers of Toxicology, showed that these chemicals altered the proteome of the respiratory cells affecting key pathways "including mitochondrial dysfunction, fatty acid metabolism, G2/M DNA damage checkpoint regulation, and mitochondrial biogenesis." Their work was recently highlighted in UCR News. Our congratulations to Prue and Man for this recognition of their work.
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