Professors Zhou and Chen Uncover Multigenerational Effects of Dicyclohexyl Phthalate

Changcheng Zhou and Qi Chen, professors in the Biomedical Sciences Division and Environmental Toxicology faculty members, and their colleagues have recently investigated the effects of paternal exposure to dicyclohexyl phthalate, or DCHP, on the metabolism of first generation (F1) and second generation (F2) offspring in mice.  As described in a UCR News article, "the researchers found that paternal DCHP exposure for four weeks led to high insulin resistance and impaired insulin signaling in F1 offspring. The same effect, but weaker, was seen in F2 offspring." Their research indicates that "paternal exposure to endocrine disrupting phthalates may have intergenerational and transgenerational adverse effects on the metabolic health of their offspring".  The research article has recently been published in Environment International. Our congratulations to Chengchang and Qi for this recognition of their important research.

 [The figure above is from the authors' Environment International article.]