Dr. Gwendolyn Gonzalez, ETOX alumna and Yinsheng Wang, Distinguished Professor of Chemistry and ETOX faculty member, were part of a research team led by Tariq Rana of UC San Diego that identified a new enzyme called, as described in the UC San Diego Today article, "phosphorylated CTD-interacting factor 1 or PCIF1, which regulates cellular entry through the mediation of N6,2-O-dimethyladenosine (m6Am) activity, an evolutionarily conserved and abundant mRNA modification. The researchers found that PCIF1 promotes the stability of both ACE2 and TMPRSS2 mRNAs, sustaining two key entry factors for SARS-CoV-2 and other coronaviruses." Their article has recently been published in the Proceedings of the National Academy of Science. Our congratulations to Gwendolyn and Yinsheng for this recognition of their important work.
Photo credit of human cell (purple) infected with SARS-COV-2 virus particles shown in yellow: NIH at https://www.nih.gov/2020/20200804-covid.jpg-1
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